As many regions lift public health measures and restart their economies, uncertainties around COVID-19 case reduction might persist. Both the World Health Organization and the Centers for Disease Control and Prevention predict a possible COVID-19 resurgence in the fall. Since the development of a vaccine is still uncertain, McKinsey & Company advises companies and governments to consider shifting online and setting remote workplace norms for the next 18–24 months. It is crucial to adapt with speed and discipline during the pandemic, while monitoring and learning from the environment to overcome uncertainty faster and build capabilities for the “next normal.”